Goal-directed resuscitation in the prehospital setting: A propensity-adjusted analysis

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In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis

INTRODUCTION We sought to investigate whether treatment of subnormal (<70%) central venous oxygen saturation (ScvO2) with inotropes or red blood cell (RBC) transfusion during early goal-directed therapy (EGDT) for septic shock is independently associated with in-hospital mortality. METHODS Retrospective analysis of a prospective EGDT patient database drawn from 21 emergency departments with a...

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Trial of early, goal-directed resuscitation for septic shock.

BACKGROUND Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertainty about its effectiveness remains. METHODS We conducted a pragmatic randomized trial with an integrated cost-effectiveness analysis in 56 hospitals in England. Patients were randomly as...

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ژورنال

عنوان ژورنال: Journal of Trauma and Acute Care Surgery

سال: 2013

ISSN: 2163-0755

DOI: 10.1097/01586154-201305000-00004